Diana Alecsandru MD, PH. D.
Physician for Reproductive Immunology at IVI Madrid
Specialists in Biomedical Sciences, Biotechnologists, Embryologists and Gynecological Doctors specialized in Reproductive Medicine
Chromosome screening and egg donation significantly increases pregnancy and delivery rates, but still not 100% of euploid embryos implant.
Other factors, not just embryo aneuploidies, might contribute to implantation failure or miscarriage, such as an imbalance in the immune maternal tolerance to pregnancy. The role of the immune system in recurrent miscarriage (RM) and recurrent implantation failure (RIF) is less known. Maternal tolerance begins at the uterine level, and successful adaptation to the semiallogeneic fetus is a complicated process. Placentation is regulated by interactions between maternal immune cells and fetal molecules, expressed by extravillous trophoblast (EVT) cells.
The maternal immune system is one of the main actors at the maternal –fetal interface, and its dysregulation as lack of activation or an overreactivity seems to influence placentation and pregnancy outcomes.